Influence of pre-B cell receptor deficiency on the immunoglobulin repertoires in peripheral blood B cells before and after immunization
Takeyuki Shimizu;Lin Sun;Kazuo Ohnishi
Molecular Immunology 166 87-100 2024年2月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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Elucidation of binding mechanism, affinity and complex structure between mWT1 tumor‐associated antigen peptide and HLA‐A*24:02
Gert‐Jan Bekker;Nobutaka Numoto;Maki Kawasaki;Takahiro Hayashi;Saaya Yabuno;Yuko Kozono;Takeyuki Shimizu;Haruo Kozono;Nobutoshi Ito;Masayuki Oda;Narutoshi Kamiya
Protein Science 32 (10) e4775-e4775 2023年10月 査読有り 研究論文(学術雑誌) 共著者
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Carboxylated polyamidoamine dendron-bearing lipid-based assemblies for precise control of intracellular fate of cargo and induction of antigen-specific immune responses
Eiji Yuba;Yoshikatsu Sugahara;Yuta Yoshizaki;Takeyuki Shimizu;Michiyuki Kasai;Keiko Udaka;Kenji Kono
Biomaterials Science 9 (8) 3076-3089 2021年4月 査読有り 研究論文(学術雑誌) 共著者
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Development of a novel monoclonal antibody that binds to most HLA-A allomorphs in a conformation-dependent yet peptide-promiscuous fashion
Toshihiro Komatsu;Takeyuki Shimizu;Makoto Kanoh;Tomoya Miyakawa;Yoko Satta;Yoshiki Yasukochi;Rika Fujimoto;Motoki Tada;Kaori Machida;Sayo Kataoka;Keiko Udaka
Immunogenetics 72 (3) 143-153 2020年4月 査読有り 研究論文(学術雑誌) 共著者
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High affinity IgM+ memory B cells are defective in differentiation into IgM antibody secreting cells by re-stimulation with a T cell-dependent antigen
Yasuyuki Tashiro, Akikazu Murakami, Yasuyoshi Hara, Takeyuki Shimizu, Masato Kubo, Ryo Goitsuka, Hidehiro Kishimoto, Takachika Azuma
Sci. Rep. 8 (1) 14559-2018年9月 査読有り 研究論文(学術雑誌) 共著者
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Distorted antibody repertoire developed in the absence of pre-B cell receptor formation
Lin Sun, Naoko Kono, Takeyuki Shimizu, Hiroyuki Toh, HANBING Xue, Osamu Numata, Manabu Ato, Shigeyuki Itakura, and Kazuo Ohnishi
Biochem. Biophys. Res. Commun. 495 1411-1417 2018年1月 査読有り 研究論文(学術雑誌) 共著者
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Deciphering antigen-responding antibody repertoires by using next-generation sequencing and confirming them through antibody-gene synthesis
Naoko Kono, Lin Sun, Hiroyuki Toh, Takeyuki Shimizu, Xue Hambing, Osamu Numata, Manabu Ato, Kazuo Ohnishi, Shigeyuki Itamura
Biochem. Biophys. Res. Commun. 487 300-306 2017年5月 査読有り 研究論文(学術雑誌) 共著者
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Somatic hypermutation of immunoglobulin genes in Rad18 knockout mice
Takeyuki Shimizu, Satoshi Tateishi, Yuki Tanoue, Takachika Azuma, Haruo Ohmori
DNA Repair 50 54-60 2016年12月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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An asymmetric antibody repertoire is shaped between plasmablast and plasma cells after secondary immunization with (4-hydroxy-3-nitrophenyl)acetyl chicken ?-globulin
Yasuyuki Tashiro, Akikazu Murakami, Ryo Goizuka, Takeyuki Shimizu, Hidehiro Kishimoto, Takachika Azuma
Int. Immunol. 27 609-620 2015年12月 査読有り 研究論文(学術雑誌) 共著者
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High affinity IgM+ memory B cells are generated through a germinal center-dependent pathway
Yasushi Hara, Yasuyuki Tashiro, Akikazu Murakami, Miyuki Nishimura, Takeyuki Shimizu, Masato Kubo, Peter D. Burrows Takachika Azuma
Mol. Immunol. 68 617-627 2015年12月 査読有り 研究論文(学術雑誌) 共著者
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Detection and isolation of anti-hapten antibody-secreting cells by cellular affinity matrix technology
Takeyuki Shimizu, Takachika Azuma
J. Immunol. Methods 422 80-86 2015年7月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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BILL-cadherin/cadherin-17 contributes to the survival of memory B cells
Shuichi Funakoshi, Takeyuki Shimizu, Osamu Numata, Fritz Melchers, and Kazuo Ohnishi
PLoS One 10 (1) e0117566-e0117566 2015年1月 査読有り 研究論文(学術雑誌) 共著者
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Low affinity IgM antibodies lacking somatic hypermutations are produced in the secondary response of C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl hapten
Akikazu Murakami, Hayato Moriyama, Mina Osako-Kabasawa, Kanako Endo, Miyuki Nishimura, Keiko Udaka, Masamichi Muramatsu, Tasuku Honjo, Takachika Azuma, and Takeyuki Shimizu
International Immunology 26 (4) 195-208 2014年4月 査読有り 研究論文(学術雑誌) 共著者
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In vivo role of aldehyde reductase
Motoko Takahashi;Satoshi Miyata;Junichi Fujii;Yoko Inai;Shigemitsu Ueyama;Motoko Araki;Tomoyoshi Soga;Reiko Fujinawa;Chiaki Nishitani;Shigeru Ariki;Takeyuki Shimizu;Tomomi Abe;Yoshito Ihara;Morimitsu Nishikimi;Yasunori Kozutsumi;Naoyuki Taniguchi;Yoshio Kuroki
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1820 (11) 1787-1796 2012年11月 査読有り 研究論文(学術雑誌) 共著者
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Pulmonary Collectins Play Distinct Roles in Host Defense against Mycobacterium avium
Shigeru Ariki;Takashi Kojima;Shinsei Gasa;Atsushi Saito;Chiaki Nishitani;Motoko Takahashi;Takeyuki Shimizu;Yuichiro Kurimura;Norimasa Sawada;Nobuhiro Fujii;Yoshio Kuroki
JOURNAL OF IMMUNOLOGY 187 (5) 2586-2594 2011年9月 査読有り 研究論文(学術雑誌) 共著者
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The amino acid residue at position 95 and the third CDR region in the H chain determine the ceiling affinity and the maturation pathway of an anti-(4-hydroxy-3-nitrophenyl)acetyl antibody
Akikazu Murakami;Yuka Takahashi;Miyuki Nishimura;Takeyuki Shimizu;Takachika Azuma
MOLECULAR IMMUNOLOGY 48 (1-3) 48-58 2010年11月 査読有り 研究論文(学術雑誌) 共著者
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Pulmonary Collectins Protect Macrophages against Pore-forming Activity of Legionella pneumophila and Suppress Its Intracellular Growth
Kaku Sawada;Shigeru Ariki;Takashi Kojima;Atsushi Saito;Masami Yamazoe;Chiaki Nishitani;Takeyuki Shimizu;Motoko Takahashi;Hiroaki Mitsuzawa;Shin-ichi Yokota;Norimasa Sawada;Nobuhiro Fujii;Hiroki Takahashi;Yoshio Kuroki
JOURNAL OF BIOLOGICAL CHEMISTRY 285 (11) 8434-8443 2010年3月 査読有り 研究論文(学術雑誌) 共著者
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Mannose binding lectin and lung collectins interact with Toll-like receptor 4 and MD-2 by different mechanisms
Takeyuki Shimizu;Chiaki Nishitani;Hiroaki Mitsuzawa;Shigeru Ariki;Motoko Takahashi;Katsuki Ohtani;Nobutaka Wakamiya;Yoshio Kuroki
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1790 (12) 1705-1710 2009年12月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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Mutational analysis of Cys(88) of Toll-like receptor 4 highlights the critical role of MD-2 in cell surface receptor expression
Chiaki Nishitani;Motoko Takahashi;Hiroaki Mitsuzawa;Takeyuki Shimizu;Shigeru Ariki;Norio Matsushima;Yoshio Kuroki
INTERNATIONAL IMMUNOLOGY 21 (8) 925-934 2009年8月 査読有り 研究論文(学術雑誌) 共著者
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Pulmonary Surfactant Protein D Binds MD-2 through the Carbohydrate Recognition Domain
Xiaomeng Nie;Chiaki Nishitani;Masami Yamazoe;Shigeru Ariki;Motoko Takahashi;Takeyuki Shimizu;Hiroaki Mitsuzawa;Kaku Sawada;Kelly Smith;Erika Crouch;Hisato Nagae;Hiroki Takahashi;Yoshio Kuroki
BIOCHEMISTRY 47 (48) 12878-12885 2008年12月 査読有り 研究論文(学術雑誌) 共著者
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Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors
Masami Yamazoe;Chiaki Nishitani;Motoko Takahashi;Tsuyoshi Katoh;Shigeru Ariki;Takeyuki Shimizu;Hiroaki Mitsuzawa;Kaku Sawada;Dennis R. Voelker;Hiroki Takahashi;Yoshio Kuroki
Journal of Biological Chemistry 283 (51) 35878-35888 2008年12月 査読有り 研究論文(学術雑誌) 共著者
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T cells specific to hapten-carrier but not to carrier alone assist in the production of anti-hapten and anti-carrier antibodies
Takeyuki Shimizu;Yuko Osaka;Chihiro Banri-Koike;Maiko Yoshida;Kanako Endo;Koji Furukawa;Masayuki Oda;Akikazu Murakami;Shuhei Ogawa;Ryo Abe;Takachika Azuma
INTERNATIONAL IMMUNOLOGY 19 (10) 1157-1164 2007年10月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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The microtubule-binding protein hook3 interacts with a cytoplasmic domain of scavenger receptor A
Hitomi Sano;Masaho Ishino;Helmut Kramer;Takeyuki Shimizu;Hiroaki Mitsuzawa;Chiaki Nishitani;Yoshio Kuroki
JOURNAL OF BIOLOGICAL CHEMISTRY 282 (11) 7973-7981 2007年3月 査読有り 研究論文(学術雑誌) 共著者
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Strategy for affinity maturation of an antibody with high evolvability to (4-hydroxy-3-nitrophenyl) acetyl hapten
Koji Furukawa;Takeyuki Shimizu;Akikazu Murakami;Ryo Kono;Masatoshi Nakagawa;Takuma Sagawa;Ichiro Yamato;Takachika Azuma
MOLECULAR IMMUNOLOGY 44 (9) 2436-2445 2007年3月 査読有り 研究論文(学術雑誌) 共著者
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The 6-fluoro-8-methoxy quinolone gatifloxacin down-regulates interleukin-8 production in prostate cell line PC-3
Koh Takeyama;Hiroaki Mitsuzawa;Chiaki Nishitani;Takeyuki Shimizu;Hitomi Sano;Yasuharu Kunishima;Satoshi Takahashi;Hiroshi Hotta;Masanori Matsukawa;Ken-ichiro Shibata;Taiji Tsukamoto;Yoshio Kuroki
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 51 (1) 162-168 2007年1月 査読有り 研究論文(学術雑誌) 共著者
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Toll-like receptor 4 region Glu(24)-Lys(47) is a site for MD-2 binding - Importance of Cys(29) and Cys(40)
Chiaki Nishitani;Hiroaki Mitsuzawa;Hitomi Sano;Takeyuki Shimizu;Norio Matsushima;Yoshio Kuroki
JOURNAL OF BIOLOGICAL CHEMISTRY 281 (50) 38322-38329 2006年12月 査読有り 研究論文(学術雑誌) 共著者
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Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice
Hiroaki Mitsuzawa;Chiaki Nishitani;Naoki Hyakushima;Takeyuki Shimizu;Hitomi Sano;Norio Matsushima;Koichi Fukase;Yoshio Kuroki
JOURNAL OF IMMUNOLOGY 177 (11) 8133-8139 2006年12月 査読有り 研究論文(学術雑誌) 共著者
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Mannose-binding lectin augments the uptake of lipid A, Staphylococcus aureus, and Escherichia coli by Kupffer cells through increased cell surface expression of scavenger receptor A
Kei Ono;Chiaki Nishitani;Hiroaki Mitsuzawa;Takeyuki Shimizu;Hitomi Sano;Hiroshi Suzuki;Tatsuhiko Kodama;Nobuhiro Fujii;Koichi Fukase;Koichi Hirata;Yoshio Kuroki
JOURNAL OF IMMUNOLOGY 177 (8) 5517-5523 2006年10月 査読有り 研究論文(学術雑誌) 共著者
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Surfactant protein a directly interacts with TLR4 and MD-2 and regulates inflammatory cellular response - Importance of supratrimeric oligomerization
Chieko Yamada;Hitomi Sano;Takeyuki Shimizu;Hiroaki Mitsuzawa;Chiaki Nishitani;Tetsuo Himi;Yoshio Kuroki
JOURNAL OF BIOLOGICAL CHEMISTRY 281 (31) 21771-21780 2006年8月 査読有り 研究論文(学術雑誌) 共著者
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Human pulmonary surfactant protein D binds the extracellular domains of toll-like receptors 2 and 4 through the carbohydrate recognition domain by a mechanism different from its binding to phosphatidylinositol and lipopolysaccharide
Madoka Ohya;Chiaki Nishitani;Hitomi Sano;Chieko Yamada;Hiroaki Mitsuzawa;Takeyuki Shimizu;Tsuyoshi Saito;Kelly Smith;Erika Crouch;Yoshio Kuroki
BIOCHEMISTRY 45 (28) 8657-8664 2006年7月 査読有り 研究論文(学術雑誌) 共著者
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Alloiococcus otitidis is a ligand for collectins and Toll-like receptor 2, and its phagocytosis is enhanced by collectins
Masanori Konishi;Chiaki Nishitani;Hiroaki Mitsuzawa;Takeyuki Shimizu;Hitomi Sano;Atsushi Harimaya;Nobuhiro Fujii;Tetsuo Himi;Yoshio Kuroki
EUROPEAN JOURNAL OF IMMUNOLOGY 36 (6) 1527-1536 2006年6月 査読有り 研究論文(学術雑誌) 共著者
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Prostate cell lines secrete IL-8 in response to Mycoplasma hominis through toll-like receptor 2-mediated mechanism
K Takeyama;H Mitsuzawa;T Shimizu;M Konishi;C Nishitani;H Sano;Y Kunishima;M Matsukawa;S Takahashi;K Shibata;T Tsukamoto;Y Kuroki
PROSTATE 66 (4) 386-391 2006年3月 査読有り 研究論文(学術雑誌) 共著者
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Generation of monoclonal antibodies against chromosomal antigens that have a high sequence similarity between human and mouse
T Higashi;S Miyakawa;S Uchiyama;S Matsunaga;H Takata;S Fujimoto;M Noda;A Terauchi;T Shimizu;M Oda;T Azuma;K Fukui
JOURNAL OF BIOTECHNOLOGY 120 (3) 262-272 2005年11月 査読有り 研究論文(学術雑誌) 共著者
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Normal immunoglobulin gene somatic hypermutation in Pol kappa-Pol iota double-deficient mice
T Shimizu;T Azuma;M Ishiguro;M Kanjo;S Yamada;H Ohmori
IMMUNOLOGY LETTERS 98 (2) 259-264 2005年5月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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Lymphocyte-expressed BILL-cadherin/cadherin-17 contributes to the development of B cells at two stages
K Ohnishi;F Melchers;T Shimizu
EUROPEAN JOURNAL OF IMMUNOLOGY 35 (3) 957-963 2005年3月 査読有り 研究論文(学術雑誌) 共著者
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Affinity maturation of secreted IgM pentamers on B cells
T Shimizu;Y Kozono;H Kozono;M Oda;T Azuma
INTERNATIONAL IMMUNOLOGY 16 (5) 675-684 2004年5月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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Estimation of the relative affinity of B cell receptor by flow cytometry
Takeyuki Shimizu;Masayuki Oda;Takachika Azuma
J. Immunol. Meth. 278 33-44 2003年5月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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The absence of DNA polymerase kappa does not affect somatic hypermutation of the mouse immunoglobulin heavy chain gene
T Shimizu;Y Shinkai;T Ogi;H Ohmori;T Azuma
IMMUNOLOGY LETTERS 86 (3) 265-270 2003年5月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus
T Shimizu;C Mundt;S Licence;F Melchers;IL Martensson
JOURNAL OF IMMUNOLOGY 168 (12) 6286-6293 2002年6月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice
C Mundt;S Licence;T Shimizu;F Melchers;IL Martensson
JOURNAL OF EXPERIMENTAL MEDICINE 193 (4) 435-445 2001年2月 査読有り 研究論文(学術雑誌) 共著者
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The identification of a nonclassical cadherin expressed during B cell development and its interaction with surrogate light chain
K Ohnishi;T Shimizu;H Karasuyama;F Melchers
JOURNAL OF BIOLOGICAL CHEMISTRY 275 (40) 31134-31144 2000年10月 査読有り 研究論文(学術雑誌) 共著者
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Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells
C Schaniel;E Pardali;F Sallusto;M Speletas;C Ruedl;T Shimizu;T Seidl;J Andersson;F Melchers;AG Rolink;P Sideras
JOURNAL OF EXPERIMENTAL MEDICINE 188 (3) 451-463 1998年8月 査読有り 研究論文(学術雑誌) 共著者
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CD8 T cells from major histocompatibility complex class II-deficient mice respond vigorously to class II molecules in a primary mixed lymphocyte reaction
Takeyuki Shimizu;Shunichi Takeda
European Journal of Immunology 27 (2) 500-508 1997年2月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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Interactions between c-kit and stem cell factor are not required for B-cell development in vivo
S Takeda;T Shimizu;HR Rodewald
BLOOD 89 (2) 518-525 1997年1月 査読有り 研究論文(学術雑誌) 共著者
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Molecular characterization of extrachromosomal circular DNAs from differentiating embryonic stem cells
Hiroshi Arakawa;Takeyuki Shimizu;Yoichiro Iwakura;Hideo Yamagishi
Cell Structure and Function 21 (6) 451-457 1996年12月 査読有り 研究論文(学術雑誌) 共著者
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MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span
Shunichi Takeda;Hans-Reimer Rodewald;Hiroshi Arakawa;Horst Bluethmann;Takeyuki Shimizu
Immunity 5 (3) 217-228 1996年7月 査読有り 研究論文(学術雑誌) 共著者
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Re-evaluation of the probabilities for productive rearrangements on the κ and λ loci
Hiroshi Arakawa;Hiroshi Arakawa;Takeyuki Shimizu;Shunichi Takeda;Shunichi Takeda
International Immunology 8 (1) 91-99 1996年1月 査読有り 研究論文(学術雑誌) 共著者
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A single retroviral gag precursor signal peptide recognized by FBL-3 tumor-specific cytotoxic T lymphocytes
T. Kondo;H. Uenishi;T. Shimizu;T. Hirama;M. Iwashiro;K. Kuribayashi;H. Tamamura;N. Fujii;R. Fujisawa;M. Miyazawa;H. Yamagishi
Journal of Virology 69 (11) 6735-6741 1995年11月 査読有り 研究論文(学術雑誌) 共著者
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Immunization with a single T helper cell epitope abrogates friend virus-induced early erythroid proliferation and prevents late leukemia development
Masaaki Miyazawa;Ryuichi Fujisawa;Chiaki Ishihara;Yumiko A. Takei;Takeyuki Shimizu;Hirohide Uenishi;Hideo Yamagishi;Kagemasa Kuribayashi
Journal of Immunology 155 (2) 748-758 1995年7月 査読有り 研究論文(学術雑誌) 共著者
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FINE-STRUCTURE OF A VIRUS-ENCODED HELPER T-CELL EPITOPE EXPRESSED ON FBL-3 TUMOR-CELLS
T SHIMIZU;H UENISHI;Y TERAMURA;M IWASHIRO;K KURIBAYASHI;H TAMAMURA;N FUJII;H YAMAGISHI
JOURNAL OF VIROLOGY 68 (12) 7704-7708 1994年12月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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MULTIPLE PRENEOPLASTIC EVENTS AND CLONAL SELECTION OF RADIATION-INDUCED MOUSE THYMIC LYMPHOMAS SHOWN BY TCR GENE REARRANGEMENTS
T SHIMIZU;M MUTO;E KUBO;T SADO;H YAMAGISHI
LEUKEMIA RESEARCH 17 (11) 959-965 1993年11月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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Molecular Characterization of Extrachromosomal Circular Dnas from an Embryonal Carcinoma Cell Line Induced to Differentiate Into Neuron-Like Cells in Vitro
Takuji Iwasato;Takeyuki Shimizu;Yasuyoshi Kanari;Hideo Yamagishi
Cell Structure and Function 18 (4) 261-266 1993年8月 査読有り 研究論文(学術雑誌) 共著者
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Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells
M. Iwashiro;T. Kondo;T. Shimizu;H. Yamagishi;K. Takahashi;Y. Matsubayashi;T. Masuda;A. Otaka;N. Fujii;A. Ishimoto;M. Miyazawa;M. N. Robertson;B. Chesebro;K. Kuribayashi
Journal of Virology 67 (8) 4533-4542 1993年8月 査読有り 研究論文(学術雑誌) 共著者
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Mouse germline transcript of TCR α joining region and temporal expression in ontogeny
Takeyuki Shimizu;Sunao Takeshita;Sunao Takeshita;Masahiro Muto;Masahiro Muto;Eiko Kubo;Eiko Kubo;Toshihiko Sado;Toshihiko Sado;Hideo Yamagishi
International Immunology 5 (2) 155-160 1993年2月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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BIASED READING FRAMES OF PREEXISTING DH-JH CODING JOINTS AND PREFERENTIAL NUCLEOTIDE INSERTIONS AT VH-DJH SIGNAL JOINTS OF EXCISION PRODUCTS OF IMMUNOGLOBULIN HEAVY-CHAIN GENE REARRANGEMENTS
T SHIMIZU;H YAMAGISHI
EMBO JOURNAL 11 (13) 4869-4875 1992年12月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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NOVEL TCR GENE REARRANGEMENTS AND EXPRESSION IN RADIATION-INDUCED THYMIC LYMPHOMAS
E KUBO;M MUTO;T SADO;S TAKESHITA;T SHIMIZU;H YAMAGISHI
JOURNAL OF RADIATION RESEARCH 33 (3) 227-242 1992年9月 査読有り 研究論文(学術雑誌) 共著者
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Deletions of immunoglobulin Cκ region characterized by the circular excision products in mouse splenocytes
Takeyuki Shimizu;Takuji Iwasato;Hideo Yamagishi;Hideo Yamagishi
Journal of Experimental Medicine 173 (5) 1065-1072 1991年5月 査読有り 研究論文(学術雑誌) 共著者(筆頭)
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